We have experience in executing Burden of Illness reviews at all stages of the process, including protocol development, search and screening, data extraction, data synthesis and final reporting. Using targeted searches and translating the results into digestible graphics (heatmaps) allows us to instantly recognise gaps in the evidence and refine the search strategy accordingly and effectively keep our clients engaged in the process. After the initial phases of the review, we also ensure accuracy of the results using iterative scoping searches and sample screening. Once the search and screening processes are complete, we can identify key markers such as lifetime costs, direct vs indirect costs, clinical burden and both societal and family/carer impacts. In addition, all the evidence is summarized with high attention to detail to inform a report that breaks down the strength of evidence by category. Where weak points of evidence are found, suitable supplementary evidence can be identified following discussion with our clients.